Lyme Depression and Anxiety Are Real

Depression, anxiety, lyme disease

Can Lyme Disease Cause Depression and Anxiety?

In this blog, we will look at Lyme Disease and mental health. You will learn:

  • How and why Lyme Disease can affect mental health
  • How to address mental health issues resulting from Lyme Disease

Do you know what Lyme Disease is and how it can affect your mental health? If you want to know more about this relatively unknown symptom of Lyme and how to best optimize your health, then this blog is for you. Please read on for answers!  

** Please note: If you want the more scientific, detailed version of this article, then please click here ** 

What is Lyme Disease (LD)?

Lyme Disease is a tick-borne illness and is often called the ‘Great Imitator’. It is contracted from a Lyme-carrying tick’s bite. It has various symptoms and can present in many ways. Doctors call it the ‘Great Imitator’ because it can imitate many other diseases. It can often go misdiagnosed or undiagnosed. Even if properly diagnosed, treatment is not always effective. Because of these issues, some people suffer quite a lot from untreated or improperly treated Lyme Disease. Their symptoms can simply show up as something the doctors don’t think is Lyme Disease. 

We have written extensively about Lyme Disease in our blogs. Please start here with some definitions of Lyme and continue reading through our blog for tons of information on Lyme Disease. In our clinic, we are experts at diagnosing and treating Lyme.

Lyme Disease & Mental Health Facts

There is increasing evidence and recognition that Lyme Disease can cause mental health symptoms (Bransfield, 2018). Lyme has immune and metabolic effects that can lead to psychiatric issues, which may include depression, anxiety disorders, developmental disorders, autism spectrum disorders, schizophrenic disorders or bipolar disorder (Bransfield, 2018)

  • One study found that patients who received a Lyme Disease diagnosis had a 28% higher rate of mental disorders (including depression & anxiety) compared to people without a Lyme diagnosis (Fallon BA, 2021). 
  • People who experience on-going symptoms post-Lyme treatment often suffer worse neurological issues. Post-treatment symptoms can linger months to years after antibiotic treatment or in people who were untreated (Fallon BA, 2021). Depression has been reported in 8-45% of patients with post-treatment Lyme symptoms (Doshi S, 2018). 
  • Lyme Disease is under-diagnosed. The real numbers on depression in people with untreated or undiagnosed Lyme Disease may be much higher. 
  • Lyme Disease can be associated with anxiety and symptoms of bipolar disorder like paranoia, delusions, hallucinations or mania (Mattingley DW, 2015).

Lyme Depression 

The most commonly reported psychiatric symptoms in people with chronic symptoms after Lyme Disease are depression and irritability (Doshi S, 2018). Getting quickly and successfully treated lowers the chances of depressive symptoms (Doshi S, 2018). 

5–20% of Lyme patients have persistent or relapsing symptoms, even after antibiotic treatment (Doshi S, 2018). Patients with persistent chronic symptoms had higher levels of depression.

In one study, 25% of all patients still suffering from symptoms post-Lyme treatment reported moderate-to-severe levels of depression (Doshi S, 2018). A different study reported this group to actually be 45% of patients, in a Lyme Disease referral center. 

What this data tells us is that depression due to Lyme Disease is not uncommon. When Lyme has been improperly diagnosed and/ or treated, people are more likely to experience depression. The chances of depression are reduced if we have an early diagnosis and successful, effective treatment (Bransfield, 2018).

Lyme Disease & Anxiety

Different types of anxiety may be caused by Lyme Disease. Symptoms may include different anxiety disorders, such as panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (Bransfield, 2018). Other common psychiatric symptoms of Lyme include mood instability, rage, panic attacks and even bipolar episodes or psychotic symptoms (Bransfield, 2018).

Panic disorder is associated with Lyme Disease. Panic disorder can happen, at some point, in up to 50% of people with Lyme (Bransfield, 2018). Although no study has specifically addressed social anxiety disorder with Lyme Disease, it is a common clinical finding in patients with a prevalence of perhaps up to 70% (Bransfield, 2018). Generalized anxiety has been associated with Lyme, and seen up to 50% of the time (Bransfield, 2018).

Obsessive compulsive disorder is classified as an anxiety disorder (Bartz JA, 2006). OCD has been reported with Lyme and can have a very sudden onset (Bransfield, 2018). In one survey of patients diagnosed with Lyme Disease, 84% were reported to have obsessive compulsive symptoms (Johnco C, 2018). 44% of these participants self-identified these symptoms as problematic and 51% reported at least some improvement in obsessive compulsive symptoms following antibiotic treatment (Johnco C, 2018).

Post-traumatic stress disorder has been associated with Lyme Disease at a prevalence of 24% (Bransfield, 2018).

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Why does Lyme Disease lead to Depression or Anxiety? 

Precisely why Lyme Disease causes mental health issues is not entirely clear. But we can think of a number of reasons why this might happen with Lyme. The question is whether mental health symptoms are due to the physiological and immunological effects of Lyme Disease, the psychological effects of having a serious illness or a combination of both of these factors (Johnco C, 2018). 

Potential Causes of Mental Health Issues are (Doshi S, 2018):

  • The immune response triggered by the Lyme bacteria microbe.
  • Inflammation: Once Lyme bacteria crosses the blood-brain barrier, it can cause nervous system and brain inflammation, which can have various effects including depression and anxiety.
  • The symptoms of Lyme itself such as pain and relapsing or chronic symptoms.
  • The psychological consequences of Lyme such as hopelessness and fear.
  • The economic stressors that come with Lyme can include loss of a job, reduced income or high health care expenses; all of which can affect a person’s mental health (Doshi S, 2018). 

Lyme Disease, like other infections in the body, can challenge the immune system. This can lead to immune effects and biochemical changes in the brain. These changes in the brain can cause neuropsychiatric symptoms (Bransfield, 2018). Sleep disorders and chronic stress can result, which can cause further disease progression and neuropsychiatric symptoms. 

Research has found that the pathological process of Lyme Disease can result in developmental and other disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, post-traumatic stress disorder), eating disorders, sleep disorders, decreased libido, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide and other serious effects (Bransfield, 2018).

Is Inflammation Really the Root of the Problem?

The inflammation throughout the body and, especially in the brain, that can happen during a Lyme Disease infection can be serious. It can lead to neurodegenerative changes that result in mental health issues. Lyme infections that have progressed to neurological symptoms can present with a variety of psychiatric symptoms: paranoia, delusions, hallucinations, depression, mania and others (Mattingley DW, 2015). 

Patients can experience psychiatric symptoms even after treatment with antibiotics. People who have been treated for Lyme Disease may have psychotic symptoms years later, as a result of the inflammation-mediated neurodegenerative damage that happened during the Lyme infection (Mattingley DW, 2015). 

We know that in neurodegenerative diseases, uncontrolled inflammation can be a strong driving force for disease progression. Interactions between damaged neurons and dysregulated brain cells can result in prolonged inflammation that drives the disease process. 

To improve recovery for Lyme sufferers, doctors need to be alert to these symptoms. Sleep disorders, fatigue, cognitive impairments, depression, anxiety disorders, chronic pain, etc. all contribute to the disease progression. Using early anti-inflammatory therapy in patients diagnosed with Lyme Disease may help to prevent inflammation-mediated neurodegenerative damage. Catching these symptoms early on is critical because these neurological, psychiatric symptoms can become permanent and irreversible if not addressed quickly (Mattingley DW, 2015).


  • Lyme Disease is an infection transmitted by a tick bite. It can present with many symptoms and can sometimes be challenging for doctors to diagnose. It is best to see a Lyme-literate doctor if you have unexplained symptoms.
  • Lyme Disease can become a chronic health issue. This is especially true in cases where Lyme Disease goes misdiagnosed or improperly treated. In these situations, symptoms can linger and become chronic. 
  • Inflammation is one of these symptoms that can linger. Systemic inflammation, and especially neuroinflammation in the brain, can be problematic. It can cause damage in many ways. 
  • Neuroinflammation in particular can present as mental health issues. For example, depression and anxiety can commonly result from Lyme Disease. It seems that the neuroinflammation is the underlying root cause. In addition, having a chronic disease like Lyme contributes to low mood and mood issues.
  • Testing for Lyme Disease is best done with a Lyme-literate doctor who can order and correctly interpret the Western Blot test to look for a Lyme or co-infection.
  • Treatment involves using herbs, antimicrobials, supplements and can include medication as part of the solution. In our clinic, we also use diet and lifestyle changes as part of the Functional Medicine approach to treating Lyme Disease.

As always, please reach out to us regarding any questions you may have about your health and healing. Our clinic has extensive expertise in diagnosing and treating a range of complicated, difficult-to-diagnose conditions. We can work on any issue(s) and partner with you to improve your health. Book a free health evaluation call with us today to see how we can help with your concerns. We can answer your questions and help you book an initial consult with one of the functional medicine doctors in our clinic. 

** Please stay tuned for our next Blog!  **

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Dr. Miles has spoken for the following organizations:

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