Pyroluria as a Cause for Anxiety, Depression, and Irritability


Do you feel an overwhelming sense of inner tension?

Have you suffered from Anxiety, Depression, or Irritability?

Do you have fits of nervous exhaustion and fearfulness?


Pyroluria is a genetic disorder that has effected many people throughout history including Charles Darwin and Emily Dickinson (1). Their behavior has reflected some of the most common symptoms of Pyroluria including…

• Irritability• Fatigue• Apathy• Depression• Emotional Outbursts• Poor appetite and smell

This imbalance is due to an abnormality in the hemoglobin synthesis. People with this disorder overproduce a bi-product of this synthesis called kryptopyrrols. These kryptopyrrols bind to necessary nutrients (such as Vitamin B6 and Zinc) that are then stripped from the bloodstream. Without the proper absorption of Vitamin B6 and Zinc you could be deficient in some of the most necessary nutrients for healthy psychiatric function.

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Who can be effected by Pyroluria?

 Anyone can be effected by additional pyrroles circulating their bodies, however Pyrroles are secreted in abnormally high amounts in the urine for…

  • 30% of schizophrenics
  • 40% of psychiatric problems
  • 11% of normal people
  • 25% of disturbed children
  • 0% of alcoholics

Pyroluria can be debilitating towards psychiatric health, without identification can lead to a life of extreme fear, nervous exhaustion, and pyrolurics can slowly become loners to avoid stressful situations, protecting themselves from the ongoing struggle.

How do I know if I have Pyroluria?

The next step to identifying if you have the stress disorder Pyroluria is through a simple urine sample to detect the amount of kryptopyrroles leaving the body. The higher the amount, the less absorption of these specific vitamins for proper brain health. We see high amounts of kryptopyrroles excreted through the urine from those diagnosed with ADHD, OCD, Autism, and Bipolar disorder.

 There is hope! Pyroluria is correctable!!

Certain vitamins are necessary for your body to create neurotransmitters which relay signals from one cell to another. This aids in brain function and creating hormones such as serotonin and nor-epinephrine which regulate mood and emotional stability. The proper removal of toxic metals such as copper, lead, cadmium, and mercury can also help our brain from develop appropriate learning skills and behavioral abilities.

Nutritional treatment in addition to an environment of low stress has been seen to be most effective. Children have been seen to benefit from discipline that is “short and sweet” rather than “long and lingering”. Pyrolurics are generally prone to relapses due to illness, injury or emotional stress.

  • Live a life free of stress
  • Create emotional stability
  • Enjoy the company of others

A simple kryptopyrrole test can be the next step into regaining your health and happiness. With our Functional Medicine approach, we can identify the root cause of your symptoms and apply real life changes to get you healthy and happy once again.

In Health and with Love,

Dr. Diane Mueller and Dr. Miles Nichols

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