Lyme Disease and Chronic Fatigue Syndrome

Lyme Disease and Chronic Fatigue Syndrome

In this Lyme Disease and Chronic Fatigue Syndrome blog, you will learn:

  • How chronic Lyme Disease and Chronic Fatigue Syndrome can look very similar to each other
  • How diagnosing, testing and treating these two conditions can be quite challenging
  • How we can apply Functional Medicine principles, look for the root causes and successfully treat Lyme Disease & Chronic Fatigue Syndrome

Do you suffer from chronic fatigue that doesn’t seem to improve? Do you have Lyme Disease or Chronic Fatigue Syndrome and do you know how to spot the difference? Then this blog is for you, as we present the link between Lyme and Chronic Fatigue. Please read on for the details! 

** Please note: If you want the longer, more detailed version of this article, then please click here **

Let’s first take a look at these individual conditions and then we will go into the interrelationship between Lyme Disease and Chronic Fatigue Syndrome.

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What is Lyme Disease (LD)? 

We have written extensively lately about Lyme Disease. LD is a tick-borne illness that causes multiple symptoms. Fatigue is one of the main symptoms. It can be difficult to diagnose and treat, depending on the individual case. Please see our blog here on ‘What is Lyme Disease?’ to understand this condition better.

What is Chronic Fatigue Syndrome (CFS)?

Chronic Fatigue Syndrome (CFS) is a condition of extreme fatigue that lasts for at least six months (CDC, 2021). The fatigue worsens with physical or mental activity, but doesn’t improve with rest. Other symptoms can include problems with sleep, cognition, pain and dizziness.

People with CFS typically have a very poor quality of life. They can’t function ‘normally’. They probably cannot perform normal daily tasks, like taking a shower or cooking a meal. They may struggle to keep a job, go to school and participate in family and social life. CFS can last for years. At least one in four CFS patients is bed- or house-bound for long periods during their illness (CDC, 2021).

CFS Causes

CFS is thought to be caused by a number of factors, such as viral infections, intracellular bacteria, environmental factors, immune system dysregulation/dysfunction and hormonal imbalances (Bjørklund G, 2019). It is thought there is an autoimmune component, as well as a microbiome/ gut component (Bjørklund G, 2019).

Viral infection is a critical factor for some CFS patients (Rasa S, 2018). In some cases, an acute viral infection (Epstein Barr, Herpes, enteroviruses, Parvovirus B19 and other viruses) can trigger the onset of CFS (Sandler CX, 2020) and (Rasa S, 2018).

CFS Diagnosis

There isn’t a straightforward definition or clear-cut criteria to define CFS (Bjørklund G, 2019). At this time, there is no diagnostic test, biomarker or treatment for CFS available in conventional medicine (Sandler CX, 2020).

In Functional Medicine, we look deeper to identify and find root causes. We would look for a previously undiagnosed underlying chronic infection, as this can often be a root cause of Chronic Fatigue Syndrome. Other potential root causes include gut dysfunction or infections, autoimmune tendencies, HPA axis issues, thyroid or other hormonal imbalances, toxic overload (particularly metals) and nutrient deficiencies.

Similarities between Lyme Disease and Chronic Fatigue Syndrome – Do they Overlap?

  • People with chronic Lyme Disease and Chronic Fatigue Syndrome are generally unable to meet the demands of a ‘normal life’. They struggle to hold a full-time job, have sleep problems and profound fatigue (Patrick DM, 2015).
  • Chronic fatigue is a key symptom across both conditions (IGenex Inc, 2021). Patients with chronic Lyme Disease also show greater cognitive problems than patients with CFS (Gaudino EA, 1997).
  • Other symptoms that can be caused by both Lyme Disease and Chronic Fatigue Syndrome are: cognitive issues, headaches, enlarged lymph nodes in the neck or armpits, unexplained muscle/ joint pain, dizziness that gets worse when sitting or standing from a lying down position and extreme exhaustion after physical or mental exercise (post-exertional malaise) (IGenex Inc, 2021).
  • Both Chronic Lyme Disease and Chronic Fatigue Syndrome are often misdiagnosed (IGenex Inc, 2021).

Chronic fatigue syndrome is a disease of exclusion. This means it is diagnosed when other disease processes are ruled out. If you have been diagnosed with chronic fatigue syndrome, we encourage you to get THOROUGHLY tested for Lyme Disease. Many of the common tests run by doctors for Lyme Disease have high rates of false negatives.

What is the Cause of Lyme Disease and Chronic Fatigue Syndrome? Is it Psychological?

These rare, complicated and multi-system diseases such as Lyme Disease and Chronic Fatigue Syndrome are often misdiagnosed as being caused by psychological issues. But the onset of a multi-system illness is rarely due to psychological causes (Bransfield RC, 2019). Many complex conditions that have been described as “all in your head” are actually immune-mediated infections (Bransfield RC, 2019). They are most likely related to the immune system and/or the microbiome. When clinical findings are confusing, the Functional Medicine approach is to find the root causes, rule out other diseases and address the problem at its root. We have extensive experience in our clinic addressing Lyme and other complex diseases (

Testing & Diagnosis is Key

To diagnose Lyme Disease, a Lyme-literate doctor should interpret a blood test called the Western Blot or a PCR test. There can be confusion about interpreting this test and many doctors interpret it incorrectly. This is why we recommend seeing a Lyme-literate doctor. If you have chronic fatigue symptoms and think you have been exposed to Lyme or other bacterial infections through a tick bite, see a doctor who can help to properly understand the Western Blot test immediately.

If chronic fatigue symptoms are caused by Lyme Disease, or another tick-borne illness, it is crucial to get the right diagnosis. Lyme, as a bacterial infection, requires specific treatment with antibiotics or natural herbal approaches. If the Lyme infection goes untreated, symptoms will not improve.

Is Mis-Diagnosis Possible or Frequent?

There are patients who are not aware of any tick bite or rash, who have symptoms like chronic fatigue and cognitive dysfunction. This could be due to Lyme Disease. These patients typically have multiple medical evaluations, but don’t receive the right testing or a precise diagnosis. They often end up being categorized as having Chronic Fatigue Syndrome, Fibromyalgia or even depression. They may be told they do not have Lyme Disease. As there are no clear-cut diagnostic criteria in these conditions, many doctors have great difficulty clinically identifying if someone thought to have Chronic Fatigue or Fibromyalgia might actually have chronic Lyme Disease (Donta, 2012).

Whether CFS or Lyme Disease (or something else) is the main cause of a person’s fatigue, we use Functional Medicine principles to find the root causes. We may uncover other reasons for the fatigue. In our clinic, we have expertise in treating a range of complicated, difficult-to-diagnose conditions like Lyme Disease and Chronic Fatigue Syndrome. We look for the root causes in our patients to identify what could be causing the symptoms. We regularly treat and resolve Lyme, chronic infections, fatigue and other complex conditions in patients in our Functional Medicine clinic.

** Please stay tuned for our next Blog!  **

Are You Suffering From A Chronic Illness?

Does your current health situation look like this…

  • Do you feel that you have tried many things and either nothing works, or the treatment does not hold?
  • Have you been told that there is nothing that can be done to reverse your illness and you just need to manage symptoms?
  • Does your illness impact your work, your family, your happiness and your social life?

We specialize in finding answers and solutions for complicated chronic illness when people feel like they have tried everything. If this sounds like you, book a free call with us to see if we are the right fit for your health goals. 

Dr. Miles has spoken for the following organizations:

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