A Novel Therapy: Kisspeptin (The Reproductive Peptide) can Help with Fertility and other Reproductive Issues

This Peptide Can Improve Fertility & Reproduction. Learn:

  • How Kisspeptin is critical for the entire process of successful reproduction
  • How Kisspeptin is important for sexual attraction & mate selection all the way through to the health of the placenta and giving birth
  • How Kisspeptin can help with infertility in both men and women
  • How Kisspeptin may prevent the spread of cancer by making cancer cells less aggressive

Do you suffer from infertility? Do you or your partner have issues such as infertility, PCOS, amenorrhea or low testosterone? Then meet a peptide called Kisspeptin that can help! Like other peptides, it can provide a novel remedy to health issues. Kisspeptin is especially great for reproductive health. Please read on for the details!  

** Please note: If you want the longer, more detailed version of this article, then please click here **

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We have recently written many blogs about peptides. To recap, a peptide is a small protein, made up of a chain of amino acids. They can be used therapeutically to help with different health conditions. Click on the links to see our articles on peptide therapyHGHCJC 1295/IpamorelinBPC 157PT 141Ta1VIPThymosin Beta 4KPVTrioSS-31, DSIP, Selank and Dihexa.

Kisspeptins are a group of peptides produced in the hypothalamus (Nejad SZ, 2017). Kisspeptin (KP) is important for successful reproduction and survival of the species (Comninos AN, 2018).

Kisspeptin triggers cellular communications and the release of various hormones (Nejad SZ, 2017). It stimulates the release of gonadotropin-releasing hormone (GnRH), causing lutenizing hormone (LH) and follicle stimulating hormone (FSH) to be released from the pituitary gland. These hormones are involved with other reproductive hormones, such as testosterone and estradiol (Nejad SZ, 2017).

KP has other effects on human behavior: it dampens fear and anxiety and has antidepressant-like effects (Comninos AN, 2018). It facilitates memory and learning (Mills EGA, 2019) and transmits information about the body's energy stores (Skorupskaite K, 2014).

Infertility is a growing problem:

  • 15% of couples today have trouble conceiving (UCLA Health, 2020)
  • 12% of women aged 15 to 44 years in the US have difficulty getting pregnant or carrying a pregnancy to term (CDC, 2021)
  • 9% of men aged 25 to 44 years in the US saw a doctor for infertility (CDC, 2021)
  • Reproductive problems in men are increasing by 1% per year in Western countries. This includes declining sperm counts, decreasing testosterone levels, increasing rates of testicular cancer and a rise in erectile dysfunction (Swan SH, 2021)
  • Sperm counts declined by 50% in just 40 years, from 1973 – 2011 (Levine H, 2017)
  • In women, miscarriage rates are increasing by 1% per year in the US (Swan SH, 2021)
  • The total fertility rate worldwide has dropped by 1% per year from 1960 to 2018 (Swan SH, 2021)
  • This is more than 10% per decade and more than 50% over 50 years (Swan SH, 2021)

Clearly, infertility is an issue today and will become even more challenging going forward. Fortunately, functional medicine has solutions. Kisspeptin can help, especially with infertility issues related to hormonal imbalances. Please contact our clinic today or go to medicinewthheart.com if you have questions about fertility and reproductive health. We follow the latest research in our functional medicine clinic so that we can bring you the most up-to-date health solutions.

The Key Benefits of Actions of Kisspeptin are:

Reproductive Health

KP helps to regulate reproduction (Skorupskaite K, 2014). Successful reproduction depends on balanced hormone levels and responses. Kisspeptin is important in many reproductive factors (Mills EGA, 2019).

Puberty & Fertility

Kisspeptin helps with puberty development and the regulation of sex hormones (Cao Y, 2019). It mediates and controls the onset of puberty (Skorupskaite K, 2014). In fact, puberty will not occur without Kisspeptin (Nejad SZ, 2017).

Low Kisspeptin levels can cause fertility problems in both men and women (Comninos AN, 2018). Adjusting Kisspeptin signaling may be used in the treatment of reproductive disorders in both men and women.

Female Reproduction

Kisspeptin is involved in normal reproductive function, female puberty, ovarian function, fertility, pregnancy, lactation and reproductive hormone balance (Nejad SZ, 2017). Adjusting Kisspeptin signaling may help to treat fertility disorders characterized by low or high reproductive hormones (Nejad SZ, 2017).


Changes in Kisspeptin may contribute to PCOS or polycystic ovary syndrome (Nejad SZ, 2017). Serum Kisspeptin levels are significantly higher in women with PCOS, which is characterized by ovulatory dysfunction (Cao Y, 2019). KP can help to normalize reproductive hormones in PCOS and may promote ovulation, and resolve PCOS (Skorupskaite K, 2014).

Male Reproduction

Testicular Kisspeptin is important for the production and development of male sperm and can induce sperm motility changes (Cao Y, 2019). Importantly, KP increases testosterone in men (Skorupskaite K, 2014).

Sexual Attraction

The attraction pathway in humans is activated by Kisspeptin (Yang L, 2020). Key brain regions that govern sexual behavior and perception of beauty are activated with KP (Yang L, 2020). Kisspeptin signaling may be a new therapy for reproductive and psychosexual disorders (Yang L, 2020).


Kisspeptin is able to prevent the spread, or metastasis, of cancer (Cao Y, 2019). It suppresses metastasis in many cancers, including gastric, esophageal carcinoma, pancreatic, ovarian, bladder and prostate cancers (Ciaramella V, 2018). Treatment with Kisspeptin reduces cancer cell aggressiveness and metastatic abilities, making the cancer less likely to spread (Ciaramella V, Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells, 2018).

Does Kisspeptin have Side Effects?

Peptides typically have no side effects and are effective in low concentrations (Khavinson V, 2020). No adverse effects from Kisspeptin have been seen (Jayasena CN, 2010).

**  Please stay tuned for our next blog on more Peptide Therapy!  **

As always, please get in touch with us. If you or someone you know is struggling with fertility or other reproductive issues or general health concerns, contact our clinic today. We can work on any issue(s) and improve your health. Book a free health evaluation call with us today, to see how we can help you with your concerns. We can answer your questions and help you book an initial consult with one of the functional medicine doctors in our clinic.

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Dr. Miles Nichols and Dr. Diane Mueller have spoken for the following organizations:

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