Focus On Mitochondrial Health To Increase Energy Production

Mitochondrial Structure and Function

Mitochondria DNA contains 37 genes. Of these, 13 are used to provide instructions to enzymes responsible for oxidative phosphorylation. This is a process that uses oxygen and sugars to create adenosine triphosphate (ATP), which is the main energy source of the cells. The other genes are responsible for making RNA. There are two types; transfer RNA (tRNA) and ribosomal RNA (rRNA). Mitochondria have several adaptations to facilitate the production of cellular energy.

The outer membrane of the mitochondrion contains enzymes that involve themselves in activities such as elongation of fatty acids and oxidation of epinephrine (Alberts bruce, 1994). Proteins found in the inner membrane perform redox reaction of oxidative phosphorylation, ATP synthesis and mitochondrion fusion and fission. The above processes are crucial in the energy production function of the mitochondrion. The cristae in the inner mitochondrion membrane serve to increase the surface area of the inner membrane-enhancing its ability to produce ATP. The matrix of the mitochondrion contains about 2/3 of all proteins. It also contains enzymes, tRNA, ribosomes and DNA which play important roles in the oxidation of pyruvate and fatty acids and citric acid cycle.

The citric acid cycle is a process that oxidizes the Acetyl-CoA to carbon dioxide. This process results in a production of reduced cofactors which are a source of electrons for electron transfer chain. GTP is also produced. This molecule is readily converted to ATP the source of fuel. The complex chain of events that eventually manifests in the body’s ability to make and use energy may be easily overlooked until a client notices any one of multiple symptoms.  A major one is fatigue.

Because mitochondria combine oxygen and fuel to produce energy, dysfunction results in less energy.  Symptoms of fatigue can potentially be related to mitochondrial dysfunction it should be considered by practitioners as a possible factor if that symptom is present.  Autoimmune, neurodegenerative and metabolic illnesses are all being studied as resulting from mitochondrial dysfunction.  Almost any cells and organs can be affected because if insufficient energy for cell function eventually causes the cell to die.  When there are no longer enough healthy cells, organs begin to fail.  Mitochondrial disorders may be caused by inherited mutations in mitochondrial DNA or in nuclear genes that determine how mitochondria develop. They may also be the result of acquired mitochondrial dysfunction due to adverse effects of drugs, infections, or other environmental causes.

Additional information supports the fact that mitochondrial DNA can be affected by oxidative stress.  According to Environmental Health Perspectives, mitochondrial DNA is more influential than nuclear genomes, on developing DNA.   Mitochondrial DNA may also be a factor in metabolic syndrome, which is growing as obesity in the population in general increases.

The United Mitochondrial Disease Foundation notes that symptoms are varied and can appear at any time from infancy to adulthood.  Many are progressive.  While no causative correlation has been definitively established, cancer, Alzheimer’s Disease, heart disease, diabetes and possibly autism are all being studied for their relationship to mitochondrial dysfunction.

Maximizing Mitochondrial Function

There are numerous recommendations for maximizing mitochondrial functioning and minimizing or repairing the damage.  Dietary changes to incorporate complex carbohydrates, healthy fats, and plant-based proteins and nutrient dense foods may be helpful.  High impact exercise also has a positive influence on mitochondrial health.  Supplements that are believed to be protective factors against mitochondrial dysfunction are magnesium, alpha lipoic acid, and B Vitamins, in addition, environmental damage can be mitigated by the use of supportive detoxification via milk thistle, turmeric, dandelion root, N-acetylcysteine and probiotics may also promote optimum mitochondrial functioning.  Boost antioxidant capacity with CoQ10, and Vitamins C, D & E. Perceived stress and actual stress also deplete some beneficial vitamins and minerals that are necessary for healthy mitochondria.  Mindfulness and stress-reducing lifestyle option can positively affect mitochondria.

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References

1. Alberts bruce, A. J. (1994). Molecular Biology of the Cell. New York: Garland publishing Inc.
2. Bradshaw. (2012). Mitochondrial DNA: The Eve Gene. New York: Bradshaw Foundation.
3. Iborra, F. J. (2004). the functional organization of mitochondrion genomes. BM Biology, 2-9.
4. Moon-Yong Cha, Don Kyu Kim, Inhee Mook-Jung. The role mitochondrial DNA mutation on neurodegenerative diseases. Exp Mol med. 2015 Mar; 47(3): el 50.
5. Satapati, S. Kucejova, B Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest. 2015 Dec 1: 125(12): 4447-446w
6. Reuter, S. Gupta, S. Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med. 2010 Dec 1; 49(11): 1603–1616.
7. Life Extension. Antioxidants, Mitochondrial Damage, and Human Aging. Available at: https://www.lifeextension.com/magazine/2006/2/report_antioxidants/page-01Accessed on July 17, 2016.
8. NIH. Genetics Home Reference. Can Changes in Mitochondrial DNA Affect Health and Development? Available at:https://ghr.nlm.nih.gov/primer/mutationsanddisorders/mitochondrialconditions Accessed on July 17, 2016.
9. Schmidt, Charles W. Environ Health Perspectives. 2010 Jul; 118(7): A292–A297. “Unraveling Environmental Effects on Mitochondria”